Neutrophil gelatinase-associated lipocalin: primary care diagnostic technology update
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چکیده
منابع مشابه
Neutrophil gelatinase-associated lipocalin: primary care diagnostic technology update.
British Journal of General Practice, October 2016 541 BACKGROUND In current clinical practice, the consensus diagnosis of acute kidney injury (AKI) depends on the detection of an acute rise in serum creatinine and/or oliguria.1 Recognition of AKI in the community is important, as it is relatively common and associated with excess mortality and morbidity.1 In a primarycare-based cohort of around...
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BACKGROUND AND OBJECTIVES A temporary deterioration in renal function during pneumoperitoneum has been reported, but the extent is not known. A new marker for the early detection of renal injury, neutrophil gelatinase-associated lipocalin (NGAL), has been shown to increase in various conditions that affect renal function. This study was conducted to explore detrimental effects of pneumoperitone...
متن کاملNeutrophil Gelatinase-Associated Lipocalin and Kidney Diseases
Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as one of the most promising biomarkers of renal epithelial injury. Numerous studies have presented the diagnostic and prognostic utility of urinary and plasma NGAL in patients with acute kidney injury, chronic kidney disease, renal injury after kidney transplantation, and other renal diseases. NGAL is a member of the lipocalin famil...
متن کاملDual action of neutrophil gelatinase-associated lipocalin.
Neutrophil gelatinase-associated lipocalin (NGAL) is expressed and secreted by immune cells, hepatocytes, and renal tubular cells in various pathologic states. NGAL exerts bacteriostatic effects, which are explained by its ability to capture and deplete siderophores, small iron-binding molecules that are synthesized by certain bacteria as a means of iron acquisition. Consistently, NGAL deficien...
متن کاملIsolation, Cloning and High- Level Expression of Neutrophil Gelatinase-Associated Lipocalin Lipocalin2 by Baculovirus Expression System through Gateway Technology
Objective(s) Lipocalin 2 (Lcn2) is a 25-kDa glycoprotein that has initially been extracted from neutrophil granules. Expression of Lcn2 is induced under various pathophysiological conditions. It is also known as an early marker of kidney and heart injury. High-level expression of recombinant Lcn2 neutrophil gelatinase-associated(NGAL) in insect cells was the aim of this study. Materials and M...
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ژورنال
عنوان ژورنال: British Journal of General Practice
سال: 2016
ISSN: 0960-1643,1478-5242
DOI: 10.3399/bjgp16x687505